Rabbit Secondary Antibodies
ABclonal Technology APC Rabbit anti-Human CD33 mAb
CD33 a type I transmembrane protein is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily and human CD33 binds preferentially to alpha-2 6-linked sialic acid Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain inhibiting cellular function such as phagocytosis In addition CD33 is also involved in other processes such as adhesion Due to its exclusive expression on hematopoietic cells particularly the myeloid lineage and their progenitors CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) CD33 may also be involved in Alzheimer s Disease
ABclonal Technology APC Rabbit anti-/Human CD55
This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis This gene is located adjacent to a closely related gene on chromosome 1
ABclonal Technology 610 Rabbit anti-Human BCL6
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
ABclonal Technology 450 Rabbit anti-Human CD94
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation Several genes of the C-type lectin superfamily including members of the NKG2 family are expressed by NK cells and may be involved in the regulation of NK cell function KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus Several transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human CD40 mAb
This gene is part of the TNF-receptor superfamily encoding a receptor on antigen-presenting cells that mediates immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation It is regulated by the AT-hook transcription factor AKNA which controls both the receptor and its ligand aiding in homotypic cell interactions The receptor interacts with TNFR2 to mediate signal transduction and is essential for amyloid-beta-induced microglial activation an early event in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple splice variants encoding different isoforms have been identified
ABclonal Technology APC Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology 488 Rabbit anti- CD226/DNAM-1
Predicted to enable integrin binding activity and protein kinase binding activity Acts upstream of or within positive regulation of interferon-gamma production and positive regulation of natural killer cell cytokine production Located in external side of plasma membrane Is expressed in embryo Orthologous to human CD226 (CD226 molecule)
Jackson Immuno Research Labs Fluorescein (FITC)-AffiniPure Rabbit Anti-Rat IgM µ Chain Specific (min X Hu Sr Prot)
Fluorescein (FITC)-AffiniPure Rabbit Anti-Rat IgM µ Chain Specific (min X Hu Sr Prot)
Immunoreagents Inc RABBIT A-RAT IGG AP
Secondary Antibody: Rabbit anti-rat IgG (H&L) - Affinity Pure, min x w/Hu Serum Proteins, Host: Rabbit, Format: Liq, Label: None, Applications: WB, ELISA, IHC/ICC, IF, IP, FC
Jackson Immuno Research Labs Alexa Fluor 488-AffiniPure Rabbit Anti-Rat IgG + IgM (H+L) (min X Hu Sr Prot)
Alexa Fluor 488-AffiniPure Rabbit Anti-Rat IgG + IgM (H+L) (min X Hu Sr Prot)
ABclonal Technology 647 Rabbit anti-Rat IgG1 Fc
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity Predicted to act upstream of or within several processes including antibody-dependent cellular cytotoxicity phagocytosis and positive regulation of immune response Predicted to be located in external side of plasma membrane and extracellular space Predicted to be part of immunoglobulin complex circulating Orthologous to human IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker))
Sigma Aldrich Fine Chemicals Biosciences ANTI-GLIS3 ANTIBODY RAB 100UL
NC3839352 ANTI-GLIS3 ANTIBODY RAB 100UL
ABclonal Technology PE Rabbit anti-Rat IgG2b Fc
Enables antigen binding activity Acts upstream of or within phagocytosis positive regulation of immune response and positive regulation of phagocytosis Located in extracellular space Part of immunoglobulin complex circulating Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)) IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)) and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker))
Jackson Immuno Research Labs Biotin-SP-AffiniPure Rabbit Anti-Rat IgG + IgM (H+L)
Biotin-SP-AffiniPure Rabbit Anti-Rat IgG + IgM (H+L)